Regional transcriptional profiling of Parkinson’s disease

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Takeaway

  • Network diffusion modelling (NDM) suggests that the substantia nigra is a likely seed region of Parkinson’s disease (PD) pathology from where atrophy spreads, and that immune-related and lysosomal PD risk factor genes can predict seed regions.

Why this matters

  • Early disease sites may be susceptible to neuroinflammation and lysosomal dysfunction, contributing to early disease propagation; these genes and pathologies may be useful as combined genetic and imaging biomarkers of PD.

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https://www.ncbi.nlm.nih.gov/pubmed/31359041
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