Impact of time to treatment on visual outcomes in optic neuritis

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  • High-dose intravenous methylprednisolone (IVMP) treatment for optic neuritis (ON) in patients (pts) with aquaporin-4 (AQP4) antibody-positive (AQP4+) and myelin oligodendrocyte glycoprotein (MOG) antibody-positive (MOG+) neuromyelitis optica spectrum disorders (NMOSDs) led to optimal visual outcomes when administered within 4 days of onset compared with delayed onset.

Why this matters

  • ON in NMOSD pts is usually responsive to corticosteroid treatment, but visual outcomes in these pts have historically been poor.

  • Previous studies have shown that early corticosteroid treatment can impact visual outcomes, but these studies included few pts with NMOSD, and no MOG+ pts.

  • These findings suggest that treatment should be administered quickly in all forms of ON, even if serotype is unknown at presentation.

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