High-dose intravenous methylprednisolone (IVMP) treatment for optic neuritis (ON) in patients (pts) with aquaporin-4 (AQP4) antibody-positive (AQP4+) and myelin oligodendrocyte glycoprotein (MOG) antibody-positive (MOG+) neuromyelitis optica spectrum disorders (NMOSDs) led to optimal visual outcomes when administered within 4 days of onset compared with delayed onset.
Why this matters
ON in NMOSD pts is usually responsive to corticosteroid treatment, but visual outcomes in these pts have historically been poor.
Previous studies have shown that early corticosteroid treatment can impact visual outcomes, but these studies included few pts with NMOSD, and no MOG+ pts.
These findings suggest that treatment should be administered quickly in all forms of ON, even if serotype is unknown at presentation.
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