Imaging markers for advanced Parkinson’s disease

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  • Neuromelanin magnetic resonance imaging (NM-MRI) appears to provide a better marker for discriminating advanced Parkinson’s disease (PD) than 123I-N-v-fluoropropyl-2b-carbomethoxy3b-(4-iodophenyl)nortropane labeled dopamine transporter by single photon emission computed tomography (DaT-SPECT).

Why this matters

  • The occurrence of motor fluctuations (MF) in PD is associated with disease progression and with worsening quality of life; therefore, monitoring the progression of nigrostriatal neuronal degeneration is useful in the management of PD.

  • Both NM-MRI and DaT-SPECT might be useful for monitoring and evaluating dopaminergic neuronal degeneration.

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